01 Set Childhood Leukemia (FDA Approaved)
In Children Leukemia is the most common cancer , accounting for almost 1 out of 3 cancers.
It is usually described either as “acute”, which grows quickly, or “chronic”, which grows slowly.
The exact cause of most cases of childhood leukemia is not known.
Therefore knowing the signs and symptoms of childhood leukemia.
Typically, most symptoms do not occur during the early stages of leukemia, and children may experience different symptoms.
Symptoms of childhood leukemia
The following are symptoms of leukemia that lead doctors to look for different types of juvenile leukemia: feelings of fatigue,repetitive viral or bacterial infections,bone and joint pain,abdominal pain which may cause loss of appetite and weight loss in a child,swollen lymph nodes under the arms, in the groin, chest and neck,easy bleeding or bruising,vomiting, rashes,weight loss ,gum problem.
The treatment is based on the child’s age, overall health, medical history, their tolerance for certain medications, procedures, and therapies(Chemotherapy, stem cell transplant )
The Fda has approved a therapy consisting of immune cells from patients, genetically modified so as to become a serial killer specialist. For now only allowed in some specific forms that do not respond to conventional treatments. Works in 83 percent of cases
The Food and Drug Administration has approved a therapy consisting of immune cells from patients, genetically modified.The therapy, is developed by Novartis and called tisagenlecleucel (trade name)
The Therapy (Leukemia)
Kymriah, belongs to the family of the so-called CART, Chimeric Antigen Receptor Therapy, which is the course of immunotherapy in oncology, but slightly delayed compared to that of the inhibitors of the checkpoint (drugs which remove imposed the brakes to the immune system by the tumor cells)
In summary, it is withdrawing the lymphocytes of each individual patient, infect them with an attenuated virus containing a protein that can act as a magnet with respect to the diseased cells, and then, once you have obtained a sufficient quantity, reinfonderli of the sick.
Analysis(Causes of Childhood leukemia)
The data that led to approval were obtained on sixty children, healed in 83% of cases. For the time being, the approval of certain types of leukemia of children and adults who do not respond to conventional therapy; in general, the CARTS are later in the tumors of the blood, because in the solid there are no technical obstacles related to the difficulty of bringing the lymphocytes into the tumor mass, but there are many studies underway to overcome this problem.
1- #Cancer, vitamin C
i- #Cancer , vitamin C counteracts leukemia: brings the cells ‘defective’ to die
Through experiments conducted on genetically modified mice it has been shown that injections with high doses of vitamin C can kill the stem cells responsible for leukemia and other blood diseases.
A research team at the Perlmutter Cancer Center, New York University (NYU) has shown that injections with high doses of vitamin C may push the stem cells defective in the bone marrow to mature and die naturally.
Therefore , these cells , instead of multiplying in an uncontrolled manner and generate tumors in the blood, such as different types of leukemias will proceed normally.
In other words, the L-ascorbic acid, better known with the common name of vitamin C, can help to combat the development and proliferation of these diffuse neoplasms.
The action of the molecule, explain the scholars, coordinated by professor Benjamin G. Neel, director of the institute and a lecturer at the Department of Medicine at NYU,
He is closely associated with that of the enzyme TET2 (Tet methylcytosine dioxygenase 2), which is involved in the development of undifferentiated stem cells.
TET2 causes them to transform into mature cells, and die normally. In 50 percent of patients suffering from myeloid leukemia, chronic, in 30 percent of those suffering from myelodysplastic syndrome, and in 10 percent of those affected by acute myeloid leukemia, there are mutations that compromise the correct functioning of this essential enzyme.
To test the effect of vitamin C, whose bond with TET2 had already been revealed by other research, scholars have created in the laboratory genetically modified mice in which the enzyme TET2 could not be activated or deactivated depending on the need.
In mice with TET2 off the stem cells behaved exactly as in humans with leukemia, which is developed in an uncontrolled manner without mature. By injecting high doses of vitamin C, the team of professor Neel is able to restore the correct operation of TET2, thus promoting proper development and maturation of the stem cells produced in the bone marrow.
The experiment worked even in mice which were injected with leukemic stem cells human, in which vitamin C is able to stop its proliferation.
The researchers explain that a therapy based on injections of vitamin C and other drugs, especially in elderly patients who cannot tolerate chemotherapy, could represent an effective method to counteract the progress of the leukemia and diseases related to it.
With regard to prevention, however, would not be sufficient only to eat the oranges are rich in vitamin C, because the concentration is too low compared to the effective intravenous. The details of the research have been published in the scientific journal Cell.